Scientists have discovered that controlling the body's DNA by suppressing the nuclear factor-kappa beta (NFkB) reaction, the body can achieve better health and longer life.
Nuclear Factor-Kappa Beta - The Key Mediator Of Aging
The 2011 volume 2 issue 6 of the journal had this to report about NFkB...
The IKK/NF-κB signaling pathway has been proposed to be one of the key mediators of aging. It is activated by genotoxic, oxidative, and inflammatory stresses and regulates expression of cytokines, growth factors, and genes that regulate apoptosis, cell cycle progression, cell senescence, and inflammation.
In mouse models, inhibition of NF-κB leads to delayed onset of age-related symptoms and pathologies. In addition, NF-κB activation is linked with many of the known lifespan regulators including insulin/IGF-1, FOXO, SIRT, mTOR, and DNA damage.
Thus NF-κB represents a possible therapeutic target for extending mammalian healthspan.
The Biomedical Research Group, Institute of Biological and Health Sciences reports that NFĸB activation has been observed in other pathologies like autism, polycistic ovary syndrome, hypertension, myocardiopathy, skeletal muscle damage, smoking-induced lung cancer, insulin resistance and type II diabetes, diabetic retinopathy, metabolic syndrome, herpes and HIV related lymphomas, viral hepatitis, pneumococcal meningitis, influenza virus infection and cocaine toxicity.
Suppressing Nuclear Factor-Kappa Beta For Better Health
Studies have found nutrients in the foods we eat can control how nuclear factor-kappa beta influences the human body. These nutrients include:
The forgone noted nutrients hold great promise scientists say, in fighting many diverse diseases and in promoting long and healthy lives.
One of the oldest remedies in Chinese medicine, and has long been used for its anti-inflammatory, anti-viral, anti-ulcer, cancer-preventive properties and is effective in the detoxification and protection of the liver.
Licorice extract inhibited NFkB activation and decreased the production of pro-inflammatory cytokines in human colon cells that had been exposed to an inflammatory challenge.
These results elegantly demonstrate how NFkB inhibition can interrupt the inflammatory cycle by which cytokines stimulate the production of still more cytokines.
Glabridin, another licorice root extract, produces similar anti-inflammatory effects by inhibiting NFkB.
Capsaicin is the main ingredient in red pepper, and has both anti-inflammatory and anti-cancer effects. And has long been used to manage inflammatory joint conditions.
Capsaicin inhibits the induction of two inflammation-provoking enzymes in stimulated macrophage immune cells. This effect is attributable to its inhibition of NFkB activation.
Capsaicin also induces cell death in many cancers by modulating NFkB.
Like curcumin, capsaicin inhibits the growth of adult T-cell leukemia cells by impairing NFkB activation.
Capsaicin further impairs cancer progression by reducing levels of vascular endothelial growth factor, thus depriving growing cancers of nutrients.
Cloves have shown in clinical studies to inhibit NFkB-mediated expression of inflammatory cytokines.
Like capsaicin, eugenol inhibits NFkB activation in stimulated macro-phage immune cells,87 reducing their synthesis of COX-2 and inflammatory cytokines.86
Oil of cloves has been used in dental care for centuries, and eugenol is now widely used to promote healing and prevent excessive inflammation after root canal surgery.
Ginger has shown in clinical studies to possess properties that inhibit the growth of tumor cell proliferation as it stimulates cancer cell death by inhibiting the effects of NFkB.
And with its anti-inflammatory activity has shown to reduce the key inflammatory enzymes COX-1 and COX-2.
This herb contains ursolic acid which has shown to reduce cancer cell proliferation and triggers tumor cell death in the early stages of cancer by turning off molecules that are required for tumor invasion and metastasis, thus inhibiting NFkB activation.
Other herbs, such as oregano, rosemary and thyme, and in the peels of fruits like apples, cranberries, and pears also contain ursolic acid.
Garlic has shown to lower the activity of NFkB by up to 41% in blood and kidney cells that had been exposed to an inflammation-provoking diet (foods that prompt inflammation), thus reducing the expression of certain cytokines.
The inhibition of nuclear factor-kappa beta by garlic compounds leads to a reduced production of chemicals that cause oxidation of lipids, and researchers think this could provide further protection from atherosclerosis.
Turmeric contains vitamins C, E and niacin. All three block the activation of NF-κB inflammatory proteins.
Turmeric oil reduces the levels of NF-κB and COX-2 inflammatory proteins. COX-2 plays a roll in cancer formation.
Following are plant compounds also found in turmeric and are pro anti-inflammatory and block the activation of NF-κB inflammatory proteins:
- Alpha-linolenic acid
- Caffeic acid
- Ferulic acid
Always consume fresh ground black pepper and turmeric together, as black pepper enhances bioavailability of turmeric.
Piperine found in black pepper can trigger TRPV1 (transient receptor potential vanilloid type-1) in the body. This triggering can reduce pain.
This fruit has been shown to induce programmed cell death and to inhibit tumor invasion, proliferation, and angiogenesis in cancers like prostate, lung, and breast cancer. It targets several proteins in the cell-signaling pathway.
The juice of pomegranates have also shown to protect healthy cells against the effects of ultraviolet B radiation by stopping ultraviolet light-stimulated nuclear factor-kappa beta activation.
Pomegranate fruit extract also prevented skin cancers due to chemicals coming in contact with the skin through NFkB-mediated effects on both the inhibition of cancer and its promotion.